CD16 anticorps
Aperçu rapide pour CD16 anticorps (ABIN1176930)
Antigène
Voir toutes CD16 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Marque
- BD Pharmingen™
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Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
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Immunogène
- Human polymorphonuclear leukocytes
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Isotype
- IgG1 kappa
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1.0 mg/mL
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Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
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Agent conservateur
- Azide free
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Stock
- 4 °C
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Stockage commentaire
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain." dans: The Journal of experimental medicine, Vol. 175, Issue 5, pp. 1381-90, (1992) (PubMed).
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: "Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain." dans: The Journal of experimental medicine, Vol. 175, Issue 5, pp. 1381-90, (1992) (PubMed).
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- CD16
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Autre désignation
- CD16
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Sujet
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The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (FcgammaRIII), a human NK-cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes.
Synonyms: FcRIII, Fc-gamma RIII, FCG3, FCGR3, FCGRIII, FcgammaRIII, IGFR3 -
Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Antigène
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